THE COMPREHENSIVE LIST OF CBD STUDIES AND REVIEWS
CBD Studies and Reviews help us understand the science behind CBD. We often wonder the effectiveness or efficacy of CBD (Cannabidiol). We read articles about how Cannabidiol will help with this ailment or have benefits for that condition. But most of the CBD studies and reviews are either difficult to find or buried in research journals, deep inside hard to find medical websites.
So we’ve done the work for you… .
A definitive and comprehensive list of CBD research and CBD studies from the top medical organizations around the world:
Articles and Listings from the US National Center for Biotechnology Information (NCBI)
World Health Organization (WHO)
US Library of Medicine posted ongoing Clinical Trials
U.S. National Institutes of Health
Listed below are the many different CBD Studies and Reviews as well as the numerous Abstracts and Articles on current CBD (Cannabidiol) research today. They cover a great number of different conditions and ailments that CBD has reportedly been able to help.
Now you can make your own conclusions based on facts!
*search studies by ailment
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Acquired Hypothyroidism
- NCBI 2017 Study: Effect of Marijuana Use on Thyroid Function and Autoimmunity.
- Bio Med Research 2015 study: Clinical Significance of Cannabinoid Receptors CB1 and CB2 Expression in Human Malignant and Benign Thyroid Lesions
- NCBI 2009 Study: Type 1 Cannabinoid Receptor-Containing Axons Innervate Hypophysiotropic Thyrotropin-Releasing Hormone-Synthesizing Neurons
- NCBI 2002 Study: Evidence for functional CB1 cannabinoid receptor expressed in the rat thyroid.
Addiction
Molecules 2019 Study: Cannabidiol Treatment Might Promote Resilience to Cocaine and Methamphetamine Use Disorders: A Review of Possible Mechanisms
Journal of Dual Diagnosis 2019 Study: The Effectiveness of Cannabinoids in the Treatment of Posttraumatic Stress Disorder (PTSD): A Systematic Review.
NCBI 2019 Abstract: The influence of carboxylesterase 1 polymorphism and cannabidiol on the hepatic metabolism of heroin.
Neurotherapuetics 2015 Study: Early Phase in the Development of Cannabidiol as a Treatment for Addiction: Opioid Relapse Takes Initial Center Stage.
AIDS and related Ailments
- NCBI 2007 Abstract: Cannabinoids in health and disease
- JPSM 2005 Article: Cannabis Use in HIV for Pain and Other Medical Symptoms
- Scientific Cannabinoid Research 2017 Article: HIV & AIDS: Cannabinoids and CBD Research Overview
- NCBI 2019 Abstract: Oral cannabinoids in people living with HIV on effective antiretroviral therapy
Alzheimer’s Disease
- Journal of Pharmacopunture 2019 Study: A Review on Studies of Marijuana for Alzheimer’s Disease – Focusing on CBD, THC
- Front Pharmacol 2017 Abstract: Evidence for Therapeutic Properties of Cannabidiol (CBD) for Alzheimer’s Disease
- Science Direct 2016 Article: Stimulation of brain glucose uptake by cannabinoid CB2 receptors and its therapeutic potential in Alzheimer’s disease
- Nature 2016 Abstract: Amyloid proteotoxicity initiates an inflammatory response blocked by cannabinoids
- Semantic Scholar 2016 Study: Activity of muscarinic, galanin and cannabinoid receptors in the prodromal and advanced stages in the triple transgenic mice model of Alzheimer’s disease
- CNS Drugs 2015 Abstract: Cannabinoids for the Treatment of Agitation and Aggression in Alzheimer’s Disease
ASCPT 2015 Abstract: Cannabinoids in late‐onset Alzheimer’s disease - Frontiers in Pharmacology 2014 Article: Cannabinoids for treatment of Alzheimer’s disease: moving toward the clinic
- Journal of Neuroinflammation 2012 Abstract: Prolonged oral cannabinoid administration prevents neuroinflammation, lowers β-amyloid levels and improves cognitive performance in Tg APP 2576 mice
- Molecular Pharmacology 2011 Abstract: Cannabidiol and Other Cannabinoids Reduce Microglial Activation In Vitro and In Vivo: Relevance to Alzheimer’s Disease
- British Pharmacological Society 2009 Abstract: Alzheimer’s disease; taking the edge off with cannabinoids
- NCBI 2005 Abstract: Cannabinol delays symptom onset in SOD1
- JNeurosci 2005 Study: Prevention of Alzheimer’s Disease Pathology by Cannabinoids
- Science Direct 2004 Abstract: Role of the endocannabinoid system in Alzheimer’s disease: New perspectives
Amyotrophic Lateral Sclerosis (ALS)
- NCBI 2019 Study: Real world experience of patients with amyotrophic lateral sclerosis (ALS) in the treatment of spasticity using tetrahydrocannabinol:cannabidiol (THC:CBD)
- Journal of General Practice 2017 Study: Co-medication with Cannabidiol May Slow Down the Progression of Motor Neuron Disease
- NCBI 2010 Abstract: Cannabis and amyotrophic lateral sclerosis: hypothetical and practical applications, and a call for clinical trials.
- NCBI 2016 Abstract: Can cannabinoids be a potential therapeutic tool in amyotrophic lateral sclerosis?
- Rense.com Article: Cannabis Relieves Lou Gehrigs Symptoms_ New Study
Anxiety Disorders
NCBI 2019 Case study: Cannabidiol in Anxiety and Sleep: A Large Case Series
NPR 2018 Article: Anxiety Relief Without The High? New Studies On CBD, A Cannabis Extract
British Journal of Pharmacology: 2017 Study: Cannabidiol regulation of emotion and emotional memory processing: relevance for treating anxiety‐related and substance abuse disorders
NCBI 2015 Publication: Cannabidiol as a Potential Treatment for Anxiety Disorders
NCBI 2019 Case study: Cannabidiol in Anxiety and Sleep: A Large Case Series
NCBI 2010 Abstract: Endocannabinoid-mediated modulation of stress responses: physiological and pathophysiological significance.
Neuropsychopharmacology. 2013 Study: Cannabinoids ameliorate impairments induced by chronic stress to synaptic plasticity and short-term memory.
NCBI 2011 Study: Cannabidiol Reduces the Anxiety Induced by Simulated Public Speaking in Treatment-Naïve Social Phobia Patients.
NCBI 2011 Report: Neural basis of anxiolytic effects of cannabidiol (CBD) in generalized social anxiety disorder: a preliminary report.
Anxiety.org 2019 Article: Is cannabis an effective treatment for anxiety disorders?
Arthritis
- NCBI 2015 Study: Transdermal cannabidiol reduces inflammation and pain-related behaviours in a rat model of arthritis
- US National Libreary of Medicine 2018 Study: Cannabinoid Delivery Systems for Pain and Inflammation Treatment
- NCBI 2017 Study: Attenuation of early phase inflammation by cannabidiol prevents pain and nerve damage in rat osteoarthritis
- NCBI 2014 Abstract: Involvement of the endocannabinoid system in osteoarthritis pain.
- NCBI 2011 Study: The abnormal cannabidiol analogue O-1602 reduces nociception in a rat model of acute arthritis via the putative cannabinoid receptor GPR55.
- NCBI 2000 Study: The nonpsychoactive cannabis constituent cannabidiol is an oral anti-arthritic therapeutic in murine collagen-induced arthritis.
- Medical News Today Article: Can CBD oil relieve arthritis pain?
- NORML Article: Rheumatoid Arthritis
Asthma
- NCBI 2015 Study: Evaluation of Serum Cytokines Levels and the Role of Cannabidiol Treatment in Animal Model of Asthma
- NCBI 2012 Study: The role of cannabinoids in inflammatory modulation of allergic respiratory disorders, inflammatory pain and ischemic stroke.
- European Journal of Pharmacology 2019 Study: Cannabidiol reduces airway inflammation and fibrosis in experimental allergic asthma.
- Hindawi report of 2015 Study: Evaluation of Serum Cytokines Levels and the Role of Cannabidiol Treatment in Animal Model of Asthma
- Journal of Cellular and Molecular Medicine 2008 Study: Activation of cannabinoid receptors prevents antigen-induced asthma-like reaction in guinea pigs.
- NCBI 1978 Abstract: Bronchodilator effect of delta1-tetrahydrocannabinol.
- CBD Insider 2018 Article: How CBD is Providing Hope for Asthma Patients
Attention Deficit Hyperactivity Disorder (ADD/ADHD)
- NCBI 2017 Study: Cannabinoids in attention-deficit/hyperactivity disorder: A randomised-controlled trial.
- Mediacal Cannibas 2018 Case report: Medical Cannabis for Adult Attention Deficit Hyperactivity Disorder
- NCBI 2012 Study: Cannabidiol and clozapine reverse MK-801-induced deficits in social interaction and hyperactivity in Sprague-Dawley rats.
- Frontiers on Pharmacology 2019 Research Article: Attenuation of Novelty-Induced Hyperactivity of Gria1-/- Mice by Cannabidiol and Hippocampal Inhibitory Chemogenetics
- University of Washington 2017 Study: Effects of Marijuana on Mental Health
Autoimmune Disease
- Gastrojournal 2019 Report: Use of Cannabidiol (CBD Oil) in Autoimmune Hepatitis
- NCBI 2013 Study: Cannabinoids decrease the th17 inflammatory autoimmune phenotype.
- NCBI 2010 Study: Cannabinoid-induced apoptosis in immune cells as a pathway to immunosuppression.
- NCBI 2006 Abstract: Targeting the CB2 receptor for immune modulation.
- Journal of Neurology 2016 Review: Cannabis and Autoimmunity – The Neurologic Perspective: A Brief Review
B
Back Pain
Spine Health 2019 Article: Understanding CBD (Cannabidiol) for Back Pain
Remedy Review 2019 Article: Can CBD provide relief from chronic back pain?
Molecules 2018 Study: Cannabinoid Delivery Systems for Pain and Inflammation Treatment
NCBI 2014 Study: Protective Effects of Cannabidiol on Lesion-Induced Intervertebral Disc Degeneration
NCBI 2008 Abstract: Cannabinoids in the management of difficult to treat pain
Bi Polar Disorder
Front Immunol 2018 Study: Translational Investigation of the Therapeutic Potential of Cannabidiol (CBD)
PsychCentral 2019 Article: CBD Oil for Depression, Schizophrenia, ADHD, PTSD, Anxiety, Bipolar & More
US. National Library of Medicine 2017 Study: Cannabidiol as an Adjunctive Treatment for Bipolar Depression (CBDBD)
University of Washington 2017 Study: Effects of Marijuana on Mental Health (Bipolar Disorder)
PLOS ONE 2016 Abstract: A Pilot Investigation of the Impact of Bipolar Disorder and Marijuana Use on Cognitive Function and Mood
Psychedelictimes 2016 Article: When Treating Bipolar Disorder with Cannabis, Research Suggests the Amount of CBD May Be Key
Journal of Psychopharmacology 2005 Abstract: Cannabinoids in bipolar affective disorder: a review and discussion of their therapeutic potential
Bone Health
NCBI 2019 Study: A Novel, Tumor-Induced Osteoclastogenesis Pathway Insensitive to Denosumab but Interfered by Cannabidiol
Journal of Bone and Mineral Research 2015 Abstract: Cannabidiol, a Major Non‐Psychotropic Cannabis Constituent Enhances Fracture Healing and Stimulates Lysyl Hydroxylase Activity in Osteoblasts
Science Direct 2016 Study: Mechanical and material properties of cortical and trabecular bone from cannabinoid receptor-1-null (Cnr1−/−) mice
Bio Med Research 2015 Article: Activation of Cannabinoid Receptor 2 Enhances Osteogenic Differentiation of Bone Marrow Derived Mesenchymal Stem Cells
Plos One 2014 Study: Protective Effects of Cannabidiol on Lesion-Induced Intervertebral Disc Degeneration
British Journal of Pharmacology 2012 Abstract: Cannabinoids and bone: endocannabinoids modulate human osteoclast function in vitro
Frontiers in Endocrinology 2012 Abstract: Role of cannabinoids in the regulation of bone remodeling
Faseb Journal 2008 Abstract: The cannabinoid CB1 receptor regulates bone formation by modulating adrenergic signaling
NCBI 2006 Abstract: Peripheral cannabinoid receptor, CB2, regulates bone mass
Brain Cancer (Tumor)
NCBI 2019 Study: Regulation of human glioblastoma cell death by combined treatment of cannabidiol, γ-radiation and small molecule inhibitors of cell signaling pathways
NCBI 2018 Study: Cannabinoids in Glioblastoma Therapy: New Applications for Old Drugs
Cancer Med 2018 Study: The current state and future perspectives of cannabinoids in cancer biology
Neuro-Oncology Practice 2017 Article: The use of cannabis in supportive care and treatment of brain tumor
Science Daily 2014 Article: Cannabis extract can have dramatic effect on brain cancer
NY Times 2019 Article: Can CBD Really Do All That?
Bulimia
Behavioural Pharmacology 2012 Abstract: The role of the endocannabinoid system in eating disorders
Europe PMC 2008 Abstract: Role of endocannabinoids and their analogues in obesity and eating disorders.
NCBI 2005 Study: Endocannabinoid control of food intake and energy balance.
C
Cancer
Disease Markers 2020 Abstract: TRPV2: A Cancer Biomarker and Potential Therapeutic Target
NCBI 2019 Abstract: Cannabinoids in cancer treatment: Therapeutic potential and legislation
Springer link 2017 Article: A review of oral cannabinoids and medical marijuana for the treatment of chemotherapy-induced nausea and vomiting
NCBI 2013 Abstract: Cannabidiol as potential anticancer drug.
NCBI 2013 Abstract: Critical appraisal of the potential use of cannabinoids in cancer management
Oncotarget 2014 Article: Cannabinoids as therapeutic agents in cancer: current status and future implications
NCBI 2011 Abstract: Anti-tumoral action of cannabinoids on hepatocellular carcinoma: role of AMPK-dependent activation of autophagy.
American Association of Cancer Research 2008 Abstract: Cannabinoids for Cancer Treatment: Progress and Promise
Europe PMC 2007 Abstract: Cannabinoids in the treatment of chemotherapy-induced nausea and vomiting
American Association of Cancer Research 2006 Abstract: Cannabinoids Induce Apoptosis of Pancreatic Tumor Cells via Endoplasmic Reticulum Stress–Related Genes
FASEB Journal 2003 Abstract: Inhibition of tumor angiogenesis by cannabinoids
NCBI 2003 Abstract: Inhibition of skin tumor growth and angiogenesis in vivo by activation of cannabinoid receptors
Cancer (Breast)
International Journal of Molecular Sciences 2020 Study: CBD Reverts the Mesenchymal Invasive Phenotype of Breast Cancer Cells Induced by the Inflammatory Cytokine IL-1β
NCBI 2019 Study: Future Aspects for Cannabinoids in Breast Cancer Therapy
Cancer Treatment Review 2012 Abstract: Cannabinoids: a new hope for breast cancer therapy?
Molecular Cancer Therapeutics 2011 Abstract: Cannabidiol Induces Programmed Cell Death in Breast Cancer Cells by Coordinating the Cross-talk between Apoptosis and Autophagy
Molecular Cancer 2010 Abstract: Cannabinoids reduce ErbB2-driven breast cancer progression through Akt inhibition
NCBI 2007 Study: Cannabidiol as a novel inhibitor of Id-1 gene expression in aggressive breast cancer cells.
Cancer (Prostate)
MarijuanaBreak 2019 Article: CBD for Prostate Cancer [Does it Work?]
Cancer Medicine 2018 Abstract: The current state and future perspectives of cannabinoids in cancer biology
NCBI 2015 Abstract: Proapoptotic effect of endocannabinoids in prostate cancer cells.
NCBI 2013 Study: Towards the use of non-psychoactive cannabinoids for prostate cancer.
NCBI 2013 Study: Non-THC cannabinoids inhibit prostate carcinoma growth in vitro and in vivo: pro-apoptotic effects and underlying mechanisms
NCBI 2012 Study: The role of cannabinoids in prostate cancer: Basic science perspective and potential clinical applications
EAUN Article: Using cannabis in prostate cancer patients
Cerebral Palsy
Frontiers of Pharmacology 2019 Study: Cannabidiol Administration Prevents Hypoxia-Ischemia-Induced Hypomyelination in Newborn Rats
Journal of Child Neurology 2018 Article: Medical Cannabis for Pediatric Moderate to Severe Complex Motor Disorders
Journal of Pain 2016 Study: An Exploratory Human Laboratory Experiment Evaluating Vaporized Cannabis in the Treatment of Neuropathic Pain From Spinal Cord Injury and Disease
Patient Education 2015 Article: Treating Cerebral Palsy Symptoms With Medical Marijuana
US National Library of Medicine 2015 Study: The Effects of Cannabis on Dystonia and Spasticity on Pediatric Patients
NCBI 2011 Abstract: Survey results of pain treatments in adults with cerebral palsy.
Chemotherapy (effects of)
Frontiers of Oncology 2018 Abstract: Enhancing the Therapeutic Efficacy of Cancer Treatment With Cannabinoids
BMJ Open 2017 Study: Oral cannabinoid-rich THC/CBD cannabis extract for secondary prevention of chemotherapy-induced nausea and vomiting
Intl. Journal of Oncology 2017 study: Anticancer effects of phytocannabinoids used with chemotherapy in leukaemia cells can be improved by altering the sequence of their administration
Current Oncology 2016 Abstract: Integrating cannabis into clinical cancer care
Cambridge University Press 2001 Abstract: Therapeutic aspects of cannabis and cannabinoids
Chronic Fatigue Syndrome
VeryWell Health 2019 Article: CBD Oil for Chronic Fatigue Syndrome
Project CBD 2019 Article: CANNABIS AND CHRONIC FATIGUE SYNDROME
The Growth Op 2019 Article: Can cannabis help with chronic fatigue syndrome?
Health Rising 2018 Article: Pinetree’s Chronic Fatigue Syndrome / M.E. CBD Oil Success Story
Chronic Pain
Sage Open 2020 Study: Medical cannibus as an alternative for opioids for chronic pain: A case report
PAIN 2019 Study: Cannabidiol modulates serotonergic transmission and reverses both allodynia and anxiety-like behavior in a model of neuropathic pain
Postgraduate Medicine 2019 Study: Evaluation of the effects of CBD hemp extract on opioid use and quality of life indicators in chronic pain patients: a prospective cohort study
PAIN-Health 2019 Article: CBD (Cannabidiol) for Chronic Pain
CNET 2019 Article: CBD for pain relief: What the science says
Science News 2018 Article: Cannabis pain relief without the ‘high’
NCBI 2018 Abstract: Cannabinoid Delivery Systems for Pain and Inflammation Treatment
Frontiers in Pharmacology 2018 Abstract: Cannabinoids and Pain: New Insights From Old Molecules
NCBI 2017 Review: Benefits and Harms of Cannabis in Chronic Pain or Post-traumatic Stress Disorder
NCBI 2008 Abstract: Cannabinoids in the management of difficult to treat pain
Colitis
Cochrane Library 2018 Study: Cannabis for the treatment of ulcerative colitis
Oxford Academic 2018 study: The Use of Cannabinoids in Colitis: A Systematic Review and Meta-Analysis
NCBI 2016 Abstract: Therapeutic Use of Cannabis in Inflammatory Bowel Disease
PLOS ONE 2010 Study: The Cannabinoid 1 Receptor (CNR1) 1359 G/A Polymorphism Modulates Susceptibility to Ulcerative Colitis and the Phenotype in Crohn’s Disease
NCBI 2009 Abstract: Cannabinoids and the gut: new developments and emerging concepts.
COVID-19
Frontiers in Immunology 2022 Study: Cannabidiol and Terpene Formulation Reducing SARS-CoV-2 Infectivity Tackling a Therapeutic Strategy
StudyFinds 2021 Article: CBD for COVID-19: Marijuana ingredient may prevent virus from causing lung damage
MDPI Life 2021 Publication: In Vitro Evaluation of the Activity of Terpenes and Cannabidiol against Human Coronavirus E229
Br J Pharmacol 2020 Abstract: The potential of cannabidiol in the COVID-19 pandemic
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Crohn’s Disease
Analytic Cannabis 2019 Article: CBD Could Treat Inflammatory Bowel Disease
Journal of Chron’s and Colitis 2019 Abstract: Cannabis, Cannabinoids, and the Endocannabinoid System—Is there Therapeutic Potential for Inflammatory Bowel Disease?
Cochrane 2018 Study: Cannabis and cannabis oil for the treatment of Crohn’s disease
NCBI 2014 Abstract: Cannabis finds its way into treatment of Crohn’s disease.
2008 Article: Cannabinoids cool the intestine
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CBD for Drug/Alcohol Addiction
CBD (Cannabidiol) derived from Cannabis has shown promise in people suffering from drug and or alcohol addiction. By relaxing the body to a calm state, hemp (cannabis) may alleviate withdrawal experienced by many drug and or alcohol addicts. Users of alcohol and other prescription drugs are searching for that “relaxing” and “calming” sensation. CBD works to combat both stress and anxiety and makes the process of quitting drugs and alcohol a lot less difficult.
MDPI 2019 Abstract: Cannabidiol Treatment Might Promote Resilience to Cocaine and Methamphetamine Use Disorders: A Review of Possible Mechanisms
Web MD 2019 Article: Could CBD Treat Opioid Addiction?
Neuropsychopharmacolgy 2019 Abstract: Unique treatment potential of cannabidiol for the prevention of relapse to drug use: preclinical proof of principle
Neurotherapuetics 2015 Study: Early Phase in the Development of Cannabidiol as a Treatment for Addiction: Opioid Relapse Takes Initial Center Stage.
NCBI 2015 study: Cannabidiol as an Intervention for Addictive Behaviors: A Systematic Review of the Evidence
Addiction Biology 2013 Study: Cannabidiol inhibits the reward-facilitating effect of morphine: involvement of 5-HT1A receptors in the dorsal raphe nucleus.
NCBI 2005 Abstract: Comparison of cannabidiol, antioxidants, and diuretics in reversing binge ethanol-induced neurotoxicity.
Dementia
Dementia Care Central 2019 Article: Using CBD (Cannabidiol) to Treat the Symptoms of Alzheimer’s & Other Dementias
The Cannigma 2019 Article: Can Cannabis Help Dementia?
U.S. National Library of Medicine 2017 Study: The Effect of Cannabis on Dementia Related Agitation and Aggression
NCBI 2017 Abstract: Cannabinoids for the treatment of dementia
NCBI 2010 Article: Cannabinoids and Dementia: A Review of Clinical and Preclinical Data
ResearchGate 2009 Study: Cannabinoids for the treatment of dementia
Depression
NCBI 2020 Study: Effects of Chronic Cannabidiol Treatment in the Rat Chronic Unpredictable Mild Stress Model of Depression
NCBI 2018 Abstract: New Perspectives on the Use of Cannabis in the Treatment of Psychiatric Disorders
Project CBD 2018 Article: CBD & THE PSYCHEDELIC RECEPTOR
Neurosychobiology 2016 Study: Prohedonic Effect of Cannabidiol in a Rat Model of Depression.
CNS & Neurological Disorders 2014 Article: Antidepressant-Like and Anxiolytic-Like Effects of Cannabidiol: A
Chemical Compound of Cannabis sativa
NCBI 2012 Abstract: Effect of Cannabinoid Receptor Activation on Spreading Depression
NCBI 2010 Study: Antidepressant-like effects of cannabidiol in mice: possible involvement of 5-HT1A receptors.
NCBI 2009 Abstract: The therapeutic potential of the endocannabinoid system for the development of a novel class of antidepressants.
Dermatomyositis
NCBI 2019 Abstract: Cannabinoid Signaling in the Skin: Therapeutic Potential of the “C(ut)annabinoid” System
Dermatol Online 2018 Review: Cannabinoids in dermatology: a scoping review.
JAAD 2017 Abstract: The role of cannabinoids in dermatology
Europe PMC 2017 Abstract: Topical cannabinoids in dermatology.
NCBI 2017 Article: Cannabinoid reduces inflammatory cytokines tumor necrosis factor alpha and type I interferons in dermatomyositis in vitro
Diabetes
Healthline 2019 Article: Can CBD Oil Be Used to Treat or Prevent Diabetes? What the Research Says
Project CBD 2017 Article: CBD AS PREVENTATIVE MEDICINE
American Diabetes 2016 Study: Efficacy and Safety of Cannabidiol and Tetrahydrocannabivarin on Glycemic and Lipid Parameters in Patients With Type 2 Diabetes
NCBI 2012 Abstract: The Endocannabinoid System and Plant-Derived Cannabinoids in Diabetes and Diabetic Complications
NCBI 2010 Abstract: Cannabidiol attenuates cardiac dysfunction, oxidative stress, fibrosis, and inflammatory and cell death signaling pathways in diabetic cardiomyopathy.
ResearchGate 2010 Abstract: The role of cannabis and cannabinoids in diabetes
NCBI 2019 Abstract: Cannabinoid Signaling in the Skin: Therapeutic Potential of the “C(ut)annabinoid” System Everyday Health 2019 Article: What to Know About CBD Skin-Care Products Science Daily 2017 Article: Cannabinoids may soothe certain skin diseases, say researchers NCBI 2007 Abstract: Cannabinoids inhibit human keratinocyte proliferation through a non-CB1/CB2 mechanism and have a potential therapeutic value in the treatment of psoriasis. E-Life 2019 Abstract: Disease-modifying effects of natural Δ9-tetrahydrocannabinol in endometriosis-associated pain Civilized 2019 Article: How I Use CBD to Treat Endometriosis Science Direct 2017 Abstract: Cannabinoid receptor 1 contributes to sprouted innervation in endometrial ectopic growth through mitogen-activated protein kinase activation Cannabas and Cannabinoid research 2017 Study: The Clinical Significance of Endocannabinoids in Endometriosis Pain Management British journal of Pharmacology 2011 Study: Δ9‐Tetrahydrocannabinol and N‐arachidonyl glycine are full agonists at GPR18 receptors and induce migration in human endometrial HEC‐1B cells Neuropsychiatric Treatment 2020 Study: Cannabinoids in the Treatment of Epilepsy: Current Status and Future Prospects U.S. Dept. of Veterans Affairs 2020 Abstract: Prospects of Cannabidiol for Easing Status Epilepticus-Induced Epileptogenesis and Related Comorbidities NCBI 2019 Study: Use of Cannabidiol in the Treatment of Epilepsy: Efficacy and Security in Clinical Trials Frontiers in Neurology 2018 Abstract: Cannabidiol for Treatment of Childhood Epilepsy–A Cross-Sectional Survey NCBI 2018 Abstract: Epilepsy and Cannabis (CBD): A Literature Review Sage Journals 2017 Abstract: Cannabidiol: Promise and Pitfalls: Cannabidiol: Promise and Pitfalls NCBI 2017 Abstract: Cannabidiol: pharmacology and potential therapeutic role in epilepsy and other neuropsychiatric disorders. NCBI 2016 Abstract: Cannabidiol in patients with treatment-resistant epilepsy: an open-label interventional trial. Science Direct 2014 Abstract: Epilepsy & Behavior NCBI 2014 Abstract: Cannabis, cannabidiol, and epilepsy–from receptors to clinical response. E
Eczema
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Endometriosis
Epilepsy
Journal of Clinical Medicine 2019 Abstract: Safety and Efficacy of Medical Cannabis in Fibromyalgia Heathline 2019 Article: CBD for Fibromyalgia Medical News Today Article: How can CBD help with fibromyalgia? Study of Pain Journal 2019 Study: An experimental randomized study on the analgesic effects of pharmaceutical-grade cannabis in chronic pain patients with fibromyalgia ResearchGate 2016 Abstract: Cannabinoids for fibromyalgia NCBI 2011 Abstract: Cannabis use in patients with fibromyalgia: effect on symptoms relief and health-related quality of life. F
Fibromyalgia
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Gastritis
NCBI 2016 Study: Therapeutic Use of Cannabis in Inflammatory Bowel Disease
NCBI 2016 Abstract: Cannabinoids, inflammation, and fibrosis.
Gastro journal 2005 Abstract: Differential Expression of Cannabinoid Receptors in the Human Colon: Cannabinoids Promote Epithelial Wound Healing
J-Stage Article 2006: EFFECTS OF ACUTE AND LONG-TERM CANNABIS TREATMENT ON RESTRAINT-INDUCED GASTRIC ULCERATION IN RATS
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Heart Disease
Plants before Pills 2020 Article: CBD Oil for Heart Disease – Health Benefits of CBD
Healthline 2019 Article: CBD for Heart Disease: Benefits, Side Effects, and Treatment
JCI Insight 2017 Anstract: A single dose of cannabidiol reduces blood pressure in healthy volunteers in a randomized crossover study
Molecular Medicine 2015 Abstract: Cannabidiol Protects against Doxorubicin-Induced Cardiomyopathy by Modulating Mitochondrial Function and Biogenesis.
British Journal of Pharmacology 2013 study: Is the cardiovascular system a therapeutic target for cannabidiol?
BMJ Journals 2011 discussion: 17 Cannabidiol as an anti-arrhythmic, the role of the CB1 receptors
NCBI 2010 Study: Cannabidiol attenuates cardiac dysfunction, oxidative stress, fibrosis, inflammatory and cell death signaling pathways in diabetic cardiomyopathy
Huntington’s Disease
CND Neurological disorder drug Targets 2017 Study: Neurological Aspects of Medical Use of Cannabidiol.
Neurotherapeutics 2015 Abstract: Neuroprotective properties of cannabigerol in Huntington’s disease: studies in R6/2 mice and 3-nitropropionate-lesioned mice.
NCBI 2012 Abstract: Cannabinoids: Novel medicines for the treatment of Huntington’s disease.
ACS Chem Neuroscience 2012 Study: Sativex-like combination of phytocannabinoids is neuroprotective in malonate-lesioned rats, an inflammatory model of Huntington’s disease: role of CB1 and CB2 receptors.
NCBI 2011 Abstract: Neuroprotective effects of phytocannabinoid-based medicines in experimental models of Huntington’s disease.
NCBI 2011 Abstract: Prospects for cannabinoid therapies in basal ganglia disorders.
NCBI 2007 Abstract: Cannabinoids in health and disease
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Hypertension
British Journal of Pharmacology 2018 Abstract: Cannabinoids in arterial, pulmonary and portal hypertension – mechanisms of action and potential therapeutic significance
Frontiers in Pharmacology 2017 Article: A Systematic Review and Meta-Analysis of the Haemodynamic Effects of Cannabidiol
JCI Insight 2017 Abstract: A single dose of cannabidiol reduces blood pressure in healthy volunteers in a randomized crossover study
NCBI 2013 Abstract: Is the cardiovascular system a therapeutic target for cannabidiol?
Journal of Pharmacology 1997 Study: Cannabinoid-Induced Hypotension and Bradycardia in Rats Is Mediated by CB1-Like Cannabinoid Receptors
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Impotence (Erectile Dysfunction)
Weedmaps 2019 Article: CBD OIL AND ERECTILE DYSFUNCTION
Healthline 2019 Article: How Does CBD Affect Your Libido, and Does It Have a Place in Your Sex Life?
CBD80 2019 Article: CBD OIL AND ERECTILE DYSFUNCTION – EVERYTHING THAT YOU SHOULD KNOW
Journal of Immunology Research 2013 Research: Treatment with CB2 Agonist JWH-133 Reduces Histological Features Associated with Erectile Dysfunction in Hypercholesterolemic Mice
Inflammatory Autoimmune Disease
Frontiers in Immunology 2018 Abstract: Cannabidiol Attenuates Experimental Autoimmune Encephalomyelitis Model of Multiple Sclerosis Through Induction of Myeloid-Derived Suppressor Cells
Frontiers in Immunology 2017 Abstract: Targeting Cannabinoid Signaling in the Immune System: “High”-ly Exciting Questions, Possibilities, and Challenges
Experimental Neurology 2017 Abstract: Mechanisms of action of cannabidiol in adoptively transferred experimental autoimmune encephalomyelitis.
NCBI 2016 Abstract: Cannabinoids, inflammation, and fibrosis.
NCBI 2014 Abstract: The endocannabinoid system: an emerging key player in inflammation.
NCBI 2011 Abstract: Cannabidiol as an Emergent Therapeutic Strategy for Lessening the Impact of Inflammation on Oxidative Stress
PLOS ONE 2011 Abstract: Cannabidiol Reduces Intestinal Inflammation through the Control of Neuroimmune Axis
NCBI 2010 Abstract: Cannabinoids as novel anti-inflammatory drugs
Insomnia
The Permanente Journal 2019 Study: Cannabidiol in Anxiety and Sleep: A Large Case Series
American Sleep Association 2019 Article: CBD: FOR SLEEP AND INSOMNIA
NCBI 2017 Abstract: Cannabis, Cannabinoids, and Sleep: a Review of the Literature.
The Sleep Doctor 2017 Article: Understanding CBD: The calming and sleep promoting benefits of cannabidiol
NCBI 2014 Study: Endocannabinoid modulation of cortical up-states and NREM sleep.
NCBI 2006 Study: Cannabidiol, a constituent of Cannabis sativa, modulates sleep in rats.
Irritable Bowel Syndrome
Biochemical Pharmacology 2018 Review: Cannabinoid pharmacology and therapy in gut disorders
Medical Marijuana Article: Cannabinoids (CBD/THC) Treat Symptoms of IBS
NCBI 2017 Abstract: Cannabinoids for treating inflammatory bowel diseases: where are we and where do we go?
Gastroenterology and Hepatology 2016 Study: Therapeutic Use of Cannabis in Inflammatory Bowel Disease
NCBI 2013 Overview: Cannabidiol in inflammatory bowel diseases: a brief overview.
NCBI 2011 Abstract: Cannabidiol reduces intestinal inflammation through the control of neuroimmune axis.
Pharmacology Therapeutics 2010 Abstract: Cannabinoids and the gut: new developments and emerging concepts.
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Leukemia
International Journal of Molecular Sciences 2021 Study: Phenolic Compounds Cannabidiol, Curcumin and Quercetin Cause Mitochondrial Dysfunction and Suppress Acute Lymphoblastic Leukemia Cells
Cell Death and Disease 2019 Study: Cannabidiol directly targets mitochondria and disturbs calcium homeostasis in acute lymphoblastic leukemia
BMC Research 2016 Research Article: Dronabinol has preferential antileukemic activity in acute lymphoblastic and myeloid leukemia with lymphoid differentiation patterns
Case Reports in Oncology 2013 Study: Cannabis Extract Treatment for Terminal Acute Lymphoblastic Leukemia with a Philadelphia Chromosome Mutation
Molecular Cancer Research 2006 Study: 9-Tetrahydrocannabinol-Induced Apoptosis in Jurkat Leukemia T Cells Is Regulated by Translocation of Bad to Mitochondria
Lou Gehrig’s Disease (ALS)
Norml 2019 Article: Study: THC/CBD Extract Associated With Reduced Spasticity In ALS Patients
Project CBD 2018 Article: AMYOTROPHIC LATERAL SCLEROSIS (ALS) AND CANNABINOIDS
Journal of General Practice 2017 Study: Co-medication with Cannabidiol May Slow Down the Progression of Motor Neuron Disease: A Case Report
NCBI 2010 Abstract: Cannabis and amyotrophic lateral sclerosis: hypothetical and practical applications, and a call for clinical trials.
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Melanoma
International Journal of Molecular Science 2020 Study: Roles of Cannabinoids in Melanoma: Evidence from In Vivo Studies
Science Direct 2019 Study: Cannabinoids as a Potential New and Novel Treatment for Melanoma: A Pilot Study in a Murine Model
Analytical Cannabis 2018 Article: Cannabinoids Shrink Tumors in New Study
Cancer Medicine 2018 Study: The current state and future perspectives of cannabinoids in cancer biology
NCBI 2009 Study: The endocannabinoid system of the skin in health and disease: novel perspectives and therapeutic opportunities.
NCBI 2003 Abstract: Inhibition of skin tumor growth and angiogenesis in vivo by activation of cannabinoid receptors.
Multiple Sclerosis (MS)
Sage Journals 2019 Study: Daily Practice Managing Resistant Multiple Sclerosis Spasticity With Delta-9-Tetrahydrocannabinol: Cannabidiol Oromucosal Spray
Multiple Sclerosis News Today 2019 Article: Pharmacist Discusses Advances, Challenges in Cannabinoids Research to Treat MS
MS Society 2019 Article: Cannabis and MS research: what’s the evidence?
Chiropractic Economics 2019 Article: CBD for MS patients: a powerhouse duo for treating multiple sclerosis
Frontiers in Neurology 2018 Abstract: Cannabidiol to Improve Mobility in People with Multiple Sclerosis
Net Doctor 2018 Article: CBD oil and MS: can cannabidiol alleviate multiple sclerosis symptoms?
Frontiers in Neurology 2017 Abstract: Cannabis and Multiple Sclerosis—The Way Forward
NCBI 2014 Study: THC:CBD spray and MS spasticity symptoms: data from latest studies.
Journal of Neurology 2005 Study: Cannabinoids in multiple sclerosis (CAMS) study: safety and efficacy data for 12 months follow up
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Obesity
NCBI 2020 Study: Phytocannabinoids: Useful Drugs for the Treatment of Obesity? Special Focus on Cannabidiol
NCBI 2018 Study: Role of Cannabinoids in Obesity
Molecular and Cellular Biochemistry 2016 Abstract: Cannabidiol promotes browning in 3T3-L1 adipocytes
Journal of Obesity 2016 study: Cannabis use in relation to obesity and insulin resistance in the Inuit population.
Frontiers in Psychology 2014 Abstract: The endocannabinoid system: directing eating behavior and macronutrient metabolism
NCBI 2012 Study: Cannabinol and cannabidiol exert opposing effects on rat feeding patterns.
Diabetologia 2008 Abstract: The endocannabinoid system in obesity and type 2 diabetes.
Dialogues In clinical Neuroscience 2017 Abstract: Cannabinoids in health and disease
Obsessive Compulsive Disorder (OCD)
Cannabis and Cannabinoid Research 2019 Abstract- The Endocannabinoid System: A New Treatment Target for Obsessive Compulsive Disorder?
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Parkinson’s Disease
US National Library of Medicine 2019 Study: A Study of Tolerability and Efficacy of Cannabidiol on Tremor in Parkinson’s Disease
NCBI 2017 Abstract: Cannabinoids in Parkinson’s Disease
Journal of Herbs, Spices & Medicinal Plants 2017 Abstract: Cannabinoid Therapeutics in Parkinson’s Disease: Promise and Paradox
Journal of Psychopharmacology 2014 Study: Effects of cannabidiol in the treatment of patients with Parkinson’s disease: An exploratory double-blind trial
NCBI 2014 Study: Cannabis (medical marijuana) treatment for motor and non-motor symptoms of Parkinson disease: an open-label observational study.
Post-Traumatic Stress Disorder (PTSD)
Journal of Dual Diagnosis 2019 Study: The Effectiveness of Cannabinoids in the Treatment of Posttraumatic Stress Disorder (PTSD): A Systematic Review.
The Journal of Alternative and Complementary Medicine 2019 Study: Cannabidiol in the Treatment of Post-Traumatic Stress Disorder: A Case Series
Nutritional Outlook 2019 Article: CBD may reduce symptoms of PTSD, says a recently published study
Frontiers in Neuroscience 2018 Study: Cannabidiol as a Therapeutic Alternative for Post-traumatic Stress Disorder: From Bench Research to Confirmation in Human Trials
Behavioral Pharmacology 2018 study: Cannabinoids and post-traumatic stress disorder: clinical and preclinical evidence for treatment and prevention
Maps Annual Report 2014 Article: Cannabinoid Science Sheds New Light on the Darkness of PTSD
Premenstrual Syndrome (PMS)
DailyCBD 2019 Article: CBD & Premenstrual Syndrome: Current Research & Understanding
Medical News Today 2019 Article: Does CBD oil work for menopause symptoms?
NCBI 2011 Abstract: Regulation of nausea and vomiting by cannabinoids
NCBI 2010 Study: The effects of Cannabis sativa L. seed (hempseed) in the ovariectomized rat model of menopause.
Psoriasis
Health.com 2019 Article: Can CBD Relieve Psoriasis Symptoms? Here’s What Doctors Are Saying
Dermatology 2018 Article: AAD 2018: Topical Cannabidiol Recommended as Adjunct Treatment for Acne, Eczema, and Psoriasis
EchoConnection 2017 Article: Psoriasis: Cannabinoids and CBD Research Overview
Current Clinical Pharmacology 2016 Abstract: Cannabis for Refractory Psoriasis-High Hopes for a Novel Treatment and a Literature Review.
Trends in Pharmacological Science 2009 Abstract: The endocannabinoid system of the skin in health and disease: novel perspectives and therapeutic opportunities.
Journal of Dermatological Science 2007 review: Cannabinoids inhibit human keratinocyte proliferation through a non-CB1/CB2 mechanism and have a potential therapeutic value in the treatment of psoriasis.
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Rheumatoid Arthritis
Healthline 2018 Article: Can CBD Oil Treat Rheumatoid Arthritis Symptoms?
NCBI 2008 Study: Characterisation of the cannabinoid receptor system in synovial tissue and fluid in patients with osteoarthritis and rheumatoid arthritis.
Rheumatology 2006 Abstract: Preliminary assessment of the efficacy, tolerability and safety of a cannabis-based medicine (Sativex) in the treatment of pain caused by rheumatoid arthritis
PNAS 2000 Abstract: The nonpsychoactive cannabis constituent cannabidiol is an oral anti-arthritic therapeutic in murine collagen-induced arthritis
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Schizophrenia
Science Direct 2017 Review: Neuronal and molecular effects of cannabidiol on the mesolimbic dopamine system: Implications for novel schizophrenia treatments
Science Direct 2017 Abstract: A systematic review of the effect of cannabidiol on cognitive function: Relevance to schizophrenia
Science Direct 2016 Abstract: Does cannabidiol have a role in the treatment of schizophrenia?
NCBI 2016 Abstract: Could cannabidiol be used as an alternative to antipsychotics?
Neurotherapeutics 2015 Study: Cannabinoids and Schizophrenia: Risks and Therapeutic Potential
NCBI 2014 Abstract: Cannabinoids and schizophrenia: therapeutic prospects.
Translational Psychiatry 2012 Abstract: Cannabidiol enhances anandamide signaling and alleviates psychotic symptoms of schizophrenia
NCBI 2009 Abstract: Cannabis and Schizophrenia Spectrum Disorders: A Review of Clinical Studies
Seizures
PNAS 2019 Article: Cannabidiol attenuates seizures and social deficits in a mouse model of Dravet syndrome
Science Daily 2019 Study: CBD clinical trial results on seizure frequency in dogs ‘encouraging’
Epilepsy and Behaviour 2018 Abstract: Cannabidiol improves frequency and severity of seizures and reduces adverse events in an open-label add-on prospective study
Frontiers in Neurology 2018 Analysis: Potential Clinical Benefits of CBD-Rich Cannabis Extracts Over Purified CBD in Treatment-Resistant Epilepsy: Observational Data Meta-analysis
Science Daily 2018 Article: Cannabidiol significantly reduces seizures in patients with severe form of epilepsy
Science Direct 2017 Study: Cannabidiol Treatment for Refractory Seizures in Sturge-Weber Syndrome
Sleep Apnea
Medical News Today 2017 Article: Cannabinoid drug found effective for treating sleep apnea
Curr Psychiatry Report 2017 Abstract: Cannabis, Cannabinoids, and Sleep: a Review of the Literature
Project CBD 2017 Article: CANNABIS & SLEEP DISTURBANCES
NCBI 2010 Study: Effect of cannabidiol on sleep disruption induced by the repeated combination tests consisting of open field and elevated plus-maze in rats.
Sleeping Disorders
Consumer Reports 2019 Article: Can CBD Help You Sleep? Some research suggests it might be worth a try.
Sleep Disorders 2017 Abstract: Cannabis, Cannabinoids, and Sleep: a Review of the Literature
PlosOne 2016 Study: Endocannabinoid Signaling Regulates Sleep Stability.
Sleep Medicine Reviews 2014 Abstract: The effects of cannabinoid administration on sleep: a systematic review of human studies.
Journal of Clinical Pharmacy and Therapeutics 2014 Report: Cannabidiol can improve complex sleep‐related behaviours associated with rapid eye movement sleep behaviour disorder in Parkinson’s disease patients.
Sage Journals 2013 Study: Effects of acute systemic administration of cannabidiol on sleep-wake cycle in rats
NCBI 2006 Study: Cannabidiol, a constituent of Cannabis sativa, modulates sleep in rats.
Spasticity
Adis Drug Evaluation 2017 Review: Delta-9-Tetrahydrocannabinol/Cannabidiol Oromucosal Spray (Sativex®): A Review in Multiple Sclerosis-Related Spasticity
Future Medicine 2016 Study: Evolution of multiple sclerosis spasticity-associated symptoms: latest data
Sage Journals 2015 Abstract: Evidence for the efficacy and effectiveness of THC-CBD oromucosal spray in symptom management of patients with spasticity due to multiple sclerosis
BMC Neurology 2009 Abstract: Whole plant cannabis extracts in the treatment of spasticity in multiple sclerosis: a systematic review
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Tobacco Addiction
Scientific Reports 2018 Abstract: The effects of cannabidiol on impulsivity and memory during abstinence in cigarette dependent smokers
Fundacion Canna Article: CBD for treating tobacco addiction?
NCBI 2018 Abstract: Cannabidiol reverses attentional bias to cigarette cues in a human experimental model of tobacco withdrawal
Neurotherapeutics 2015 Study: Early Phase in the Development of Cannabidiol as a Treatment for Addiction: Opioid Relapse Takes Initial Center Stage.
Sage Journals 2015 Review: Cannabidiol as an Intervention for Addictive Behaviors: A Systematic Review of the Evidence
Science Direct 2013 Study: Cannabidiol reduces cigarette consumption in tobacco smokers: Preliminary findings.
Tourette Syndrome
The International Journal of Psychiatry in Medicine 2018 Study: Pure delta-9-tetrahydrocannabinol and its combination with cannabidiol in treatment-resistant Tourette syndrome: A case report
Psychiatryonline.org 2017 Abstract: Preliminary Evidence on Cannabis Effectiveness and Tolerability for Adults With Tourette Syndrome
NCBI 2017 Study: Significant Tic Reduction in An Otherwise Treatment-Resistant Patient with Gilles de la Tourette Syndrome Following Treatment with Nabiximols
Behavioral Neurology 2013 Abstract: Treatment of Tourette syndrome with cannabinoids.
NCBI 2008 Abstract: Cannabinoids: possible role in patho-physiology and therapy of Gilles de la Tourette syndrome.
We will update weekly as the CBD Studies and Reviews come in…so check back often as the newest and most relevant CBD Studies and CBD reviews will be posted here.
*CBD has been shown to be effective in treating a vast range of ailments and their symptoms. CBD by no means is a “cure” for these diseases and ailments mentioned above, but these studies are to be referenced and used as a suggested resource to better understand the affects of CBD and the human body. The CBD studies and reviews show much promise for CBD, but do not substitute for the medical advice as given by your doctor. Always speak to your doctor first before trying CBD. You should be at least 18 years of age to use CBD products.